Teen smoking, field cancerization, and a "critical period" hypothesis for lung cancer susceptibility.

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Teen smoking, field cancerization, and a "critical period" hypothesis for lung cancer susceptibility.

Cigarette smoking by children and adolescents continues to be prevalent, and this fact represents a major public health problem and challenge. Epidemiologic work has previously suggested that exposure of the lung to tobacco carcinogens at an early age may be an independent risk factor for lung cancer. Recent studies at the molecular and cellular levels are consistent with this, now suggesting t...

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The Incidence of Lung Cancer and Smoking in Iran, Turkey, England, and USA: A Comparative Study

Introduction: lung cancer is the deadliest and the costliest cancer in the world. In this study, we have tried to compare the situation of this disease in several countries by considering the most important risk factor of lung cancer (smoking cigarette). Method: This is a comparative study, a comprehensive one which was done on lung cancer rates in four countries, Iran, Turkey, England and UAS...

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Erratum: Field Cancerization in Sporadic Colon Cancer

In the version of this article initially published, the first affiliation (affiliation number 1) was incorrectly stated as "Division of Gastroentorology, Department of Internal Medicine." The correct affiliation is "Department of Internal Medicine."

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Field Cancerization in Sporadic Colon Cancer

BACKGROUND/AIMS Aberrant DNA methylation has a specific role in field cancerization. Certain molecular markers, including secreted frizzled-related protein 2 (SFRP2), tissue factor pathway inhibitor 2 (TFPI2 ), N-Myc downstream-regulated gene 4 (NDRG4) and bone morphogenic protein 3 (BMP3), have previously been shown to be hypermethylated in colorectal cancer (CRC). We aim to examine field canc...

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Sentence Processing Among Native vs. Nonnative Speakers: Implications for Critical Period Hypothesis

The present study intended to investigate the processing behavior of 2 groups of L2 learners of English (high and mid in proficiency) and a group of English native speakers on English active and passive reduced relative clauses. Three sets of tasks, an offline task, and 2 online tasks were conducted. Results revealed that the high-proficiency group’s performance was the same as that of the nati...

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ژورنال

عنوان ژورنال: Environmental Health Perspectives

سال: 2002

ISSN: 0091-6765,1552-9924

DOI: 10.1289/ehp.02110555